Dr. Ware will present his annual lecture entitled “New Techniques for Health Outcomes Measurement and Evaluation” at the Measurement, Design, and Analysis Methods for Health Outcomes Research course held from September 25-27 at the Harvard School of Public Health. The lecture will cover the 40-year evolution of survey content and noteworthy milestones in the history of patient-reported outcomes (PROs) as well as some of the most innovative and important recent conceptual and methodological advances. The latter include new features of items shown to improve their performance over legacy items, standardized underlying metrics for the domains common to most legacy generic PROs, and a new generation of standardized disease-specific PROs that fill the gap between disease-specific symptoms that are not QOL and generic QOL measures that are not disease-specific. In the afternoon workshop, entitled “The How and Why of Integrating Disease-Specific and Generic Patient-Reported Outcome Measures (PROMS)”, Dr. Ware will discuss the use of QOL impact attributions to specific diseases to improve the validity and responsiveness of disease-specific measures, how improved measures can be integrated and compared in a profile that can be standardized across diseases, and the first norm-based scoring for disease-specific measures for the chronically-ill population. Case studies from early adoptions of these advances in academic medical center applications and clinical trials will be discussed.